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Participants completed an audio computer-assisted self-interview followed by HIV testing. Respondent-driven sampling 11, 12 was used to recruit participants. Participation was open to men who were HIV positive, HIV negative, or of unknown serostatus.

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Candidates had to be male (and identify as such) be 18 years or older self-identify as Black, African American, or Latino and report sexual intercourse (oral, anal sex, or mutual masturbation) with a man in the past 12 months. Men were enrolled from May 2005 to April 2006 in Philadelphia, Los Angeles, and New York City. The Brothers y Hermanos study recruited Black and Latino MSM to examine factors associated with HIV risk behavior and HIV infection. Data were collected as part of a study funded by the Centers for Disease Control and Prevention.

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